HORDB

ID: hor004602
Uniprot ID: Q9I955
Protein name: Thymosin beta-a
Gene name: NA
Organism: Cyprinus carpio (Common carp)
Family: Thymosin beta family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Cyprinus (genus), Cyprininae (subfamily), Cyprinidae (family), Cyprinoidei (suborder), Cypriniformes (order), Cypriniphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0003779 actin binding; GO:0003785 actin monomer binding
GO BP: GO:0007015 actin filament organization
GO CC: GO:0005737 cytoplasm; GO:0005856 cytoskeleton

Function: Plays an important role in the organization of the cytoskeleton.
Mechanism: Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004602_AF2.pdb

hor004602_ESM.pdb

Mass:	584765	Formula:	C215H359N61O77S
Absent amino acids:	HMRWY	Common amino acids:	K
pI:	6.64	Basic residues:	10
Polar residues:	11	Hydrophobic residues:	9
Hydrophobicity:	-158.67	Boman Index:	-14705
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	45.56
Instability Index:	3245.78	Extinction Coefficient cystines:	0
Absorbance 280nm:	0